In a large bowl, combine beef, Worcestershire sauce, garlic powder, salt, pepper, and onion powder until well mixed but not overmixed (your hands work great for this!).
Form beef mixture into 4 even patties (about 1/2-inch thick), and make a slight indentation in the middle of each burger.
Place in air fryer basket and set temperature to 380ºF. Cook for 7 minutes, flip, and cook for an additional 3-5 minutes. When fully cooked, internal temperature of burgers should be 160ºF for a well done burger (see note). Burgers will continue to cook after they are removed from the air fryer so if they are 150ºF to 155ºF, you can take them out. Don't overcook the burgers or they'll get too dry.
If desired, add a slice of cheese when burgers have finished cooking, return to air fryer and let the residual heat melt the cheese (should take a minute or less).
We tested the recipe with both 85% lean and 92% lean ground beef and found them to be very similar. Choose what you like best! Nutrition information is based on 85% lean ground beef.
Use a quick read meat thermometer to check the internal temperature of your burgers in the thickest middle part of the patty. Air fryers vary and cooking time also varies depending on the thickness of the hamburger patties, so checking the internal temperature of the hamburgers is the best way to ensure they’re cooked perfectly.
For frozen patties, increase cooking time. Cook for 9 minutes, flip, and continue to cook for 6-9 minutes or until internal temperature reaches 160ºF.